Publications

Peer-reviewed publications

Research investigations

2022

Ortug A, Yuzbasioglu N, Akalan N, Levman J, Takahashi E. Preoperative and postoperative high angular resolution diffusion imaging tractography of cerebellar pathways in posterior fossa tumors. Clinical Anat. 2022. In press. doi.org/10.1002/ca.23914

Levman J**, Forgeron C, Shiohama T, MacDonald P, Stewart N, Lim A, Takahashi E. Cortical thickness abnormalities in attention deficit hyperactivity disorder revealed by structural magnetic resonance imaging: newborns to young adults. Int J Dev Neurosci. 2022. In press.

Shiohama T, Stewart N, Nangaku M, van der Kouwe AJW, Takahashi E. Identification of association fibers using ex vivo diffusion tractography in Alexander disease brains. J Neuroim. 2022. In press

Akaba Y, Shiohama T, Komaki Y, Seki F, Ortug A, Sawada D, Uchida W, Kamagata K, Shimoji K, Aoki S, Takahashi S, Suzuki T, Natsume J, Takahashi E, Tsujimura K. Comprehensive volumetric analysis of Mecp2-null mouse model for Rett syndrome by T2-weighted 3D magnetic resonance imaging. Front Neurosci. 2022. 16:885335.

2021

Guo Y‡, Ortug A‡, Sadberry R, Rezayev A, Levman J, Shiohama T, Takahashi E. Symptom-related differential neuroimaging biomarkers in children with corpus callosum abnormalities. Cereb Cortex 2021. 31: 4916- 4932. (‡ co-first authors) Link to file >>

Shiohama T, Ortug A, Alatorre Warren JL, Valli B, Levman J, Faja SK, Tsujimura K, Maunakea AK, Takahashi E. Small nucleus accumbens and large cerebral ventricles in infants and toddlers prior to receiving diagnoses of autism spectrum disorder. Cereb Cortex 2021. Aug 28. doi: 10.1093/cercor/bhab283 [Epub ahead of print] Link to file >>

Levman J, Das A, MacDonald A, MacDonald P, Stewart N, Lim A, Berrigan L, Takahashi E. Clinically detectable structural abnormalities in pediatric onset multiple sclerosis: A large-scale magnetic resonance imaging analysis. Int J Dev Neurosci. 2021. 81:200-208. Link to file >>

Levman J, Jennings M, Kabaria P, Rouse E, Nangaku M, Berger D, Gondra I, Takahashi E, Tyrrell P. Hold-out validation for the assessment of stability and reliability of multivariable regression demonstrated with magnetic resonance imaging of patients with schizophrenia. Int J Dev Neurosci. 2021 Jul 26. doi:10.1002/jdn.10144. [Epub ahead of print] Link to file >>

Tompkins G, Levman J, Ijner P, Shiohama T, Takahashi E. Cortical thickness in clinical Moyamoya disease: a magnetic resonance imaging study. Int J Dev Neurosci. 2021. Aug 9. doi: 10.1002/jdn.10146 [Epub ahead of print] Link to file >>

McCann B, Levman J, Baumer N, Lam MY, Shiohama T, Cogger L, MacDonald A, Ijner P, Takahashi E. Structural magnetic resonance imaging demonstrates volumetric brain abnormalities in Down syndrome: Newborns to young adults. Neuroimage:Clin. 2021. Sep 3; 32:102815. doi: 10.1016/j.nicl.2021.102815 [Epub ahead of print] Link to file >>

Ijner P, Tompkins G, Shiohama T, Takahashi E, Levman J. Structural abnormalities in pediatric moyamoya disease revealed by clinical magnetic resonance imaging, regionally distributed relative signal intensities and volumes. Int J Dev Neurosci. 2021. Dec 30. https://doi.org/10.1002/jdn.10167

2020

Charvet CJ, Das A, Song JW, Tindal-Burgess DJ, Kabaria P, Dai G, Kane T, Takahashi E. High angular resolution diffusion MRI reveals conserved and deviant programs in the paths that guide human cortical circuitry. Cereb Cortex 2020. 30:1447-1464. Link to file >>

Hendy JP, Takahashi E, Van der Kouwe A, Charvet CJ. Brain wiring and supragranuar-enriched genes linked to protracted human frontal cortex development. Cereb Cortex 2020. 30:5654-5666. Link to file >>

Shiohama T, Chew B, Levman J, Takahashi E. Quantitative analyses of high angular resolution diffusion imaging (HARDI)-derived long association fibers in children with sensorineural hearing loss. Int J Dev Neurosci. 2020. 80:717-729. Link to file >>

 

2019

Charvet CJ, Palani A, Kabaria P, Takahashi E. Evolution of brain connections: integrating diffusion MR tractography with gene expression highlights increased cortico-cortical projections in primates. Cereb Cortex 2019. 29:5150-5165. Link to file >>

Levman J, Fang Z, Zumwalt K, Cogger L, Vasung L, MacDonald P, Lim A, Takahashi E. Asymmetric insular connectomics revealed by diffusion magnetic resonance imaging analysis of healthy brain development. Brain Connect. 2019. 9:2-12. Link to file >>

Levman J, MacDonald P, Rowley S, Stewart N, Lim A, Ewenson B, Galaburda AM, Takahashi E. Structural magnetic resonance imaging demonstrates abnormal regionally-differential cortical thickness variability in pediatric autism. Front Hum Neurosci. 13:75. 2019. Link to file >>

Levman J, MacDonald A, Baumer N, MacDonald P, Stewart N, Lim A, Cogger L, Shiohama T, Takahashi E. Structural magnetic resonance imaging demonstrates abnormal cortical thickness in Down syndrome: Newborns to young adults. Neuroimage:Clin. 2019. 23:101874. Link to file >>

Shiohama T, Levman J, Takahashi E. Surface- and voxel-based brain morphologic study in Rett and Rett-like syndrome with MECP2 mutation. 2019. Int J Dev Neurosci. 73:83-88 Link to file >>

Shiohama T, Levman J, Baumer N, Takahashi E. Structural MRI-based brain morphology study in infants and toddlers with Down syndrome; the effect of comorbidities. Pediatr Neurol. 2019. 100:67-73. Link to file >>

Shiohama T, McDavid J, Levman J, Takahashi E. Quantitative brain morphological analysis in CHARGE syndrome. Neuroimage:Clin. 2019. 23: 101866. Link to file >>

Shiohama T, McDavid J, Levman J, Takahashi E. The left lateral occipital cortex exhibits decreased thickness in children with sensorineural hearing loss. Int J Dev Neurosci. 2019. 76:34-40. Link to file >>

Vasung L, Rezayev A, Yun H, Song JW, Van der Kouwe A, Stewart N, Palani A, Shiohama T, Chouinard-Decorte F, Levman J, Takahashi E. Structural and diffusion MRI analyses with histological observations in patients with lissencephaly. Front Cell Dev Biol. 2019. 7:124. Link to file >>

 

2018

Das A, Takahashi E. Characterization of white matter tracts by diffusion MR tractography in cat and ferret that have similar gyral patterns. Cereb Cortex. 2018. 28:1338-1347. Link to file >>

Das A, Takahashi E. Neuronal migration and axonal pathways linked to human fetal insular development revealed by diffusion MR tractography. 2018. Cereb Cortex. 28:3555-3563. Link to file >>

Levman J, Takahashi E, Forgeron C, MacDonald P, Stewart N, Lim A, Martel A. A sorting statistic with application in neurological magnetic resonance imaging of autism. J. Healthcare Eng. 2018. 71:34-45. Link to file >>

Levman J, Vasung L, MacDonald P, Rowley S, Stewart N, Lim A, Ewenson B, Galaburda AM, Takahashi E. Regional volumetric abnormalities in pediatric autism revealed by structural magnetic resonance imaging. 2018. Int J Dev Neurosci. 71:34-45. Link to file >>

Kang D-W, Kim D, Chang L-H, KimY-H, Takahashi E, Cain MS, Watanabe T, Sasaki Y. Structural and functional connectivity changes beyond visual cortex in a later phase of visual perceptual learning. 2018. Sci Rep. 8:5186 Link to file >>

Rezayev A, Feldman HA, Levman J, Takahashi E. Reduced thalamocortical connectivity in focal cortical dysplasia. Brain Res. 2018. 1694:38-45. Link to file >>

 

2017

Wilkinson M, Kane T, Wang R, Takahashi E. Migration pathways of thalamic neurons and development of thalamocortical connections in humans revealed by diffusion MR tractography. 2017. Cereb Cortex. 27:5683-5695. Link to file >>

Wilkinson M, Lim AR, Cohen AH, Galaburda AM, Takahashi E. Detection and growth pattern of arcuate fasciculus from newborn to adult. 2017. Front Neurosci. 11:389. Link to file >>

Charvet C, Hof P, Raghanti MA, van der Kouwe A, Sherwood C, Takahashi E. Combining diffusion MR tractography with stereology highlights increased cross-cortical integration in primates. J Comp Neurol. 2017. 525:1075-1093. Link to file >>

Charvet CJ, Šimić G, Kostović I, Kovačević V, Vukšić M, Leko MB, Takahashi E, Sherwood CC, Wolfe MD, Finlay BL. Co-evolution in the timing of GABAergic and pyramidal maturation in primates. Proc Royal Soc B: Biol Sci. 2017. 284:1861. Link to file >>

Kanamaru Y, Li J, Stewart N, Sidman RL, Takahashi E. Cerebellar pathways in mouse model of Purkinje cell degeneration detected by high-angular resolution diffusion imaging tractography. 2017. Cerebellum. 16:648-655. Link to file >>

Vasung L, Raguz M, Kostovic I, Takahashi E. Spatiotemporal relationship of brain pathways during human fetal development using high-angular resolution diffusion MR imaging and histology. 2017. Front Neurosci. 11:348. Link to file >>

Wang R, Wilkinson M, Kane T, Takahashi E. Convergence of cortical, thalamocortical, and callosal pathways during human fetal development revealed by diffusion MRI tractography. Front Neurosci. 2017. 11:576. Link to file >>

Levman J, MacDonald P, Lim AR, Takahashi E. A pediatric structural MRI analysis of healthy brain development from newborns to adults. Hum Brain Mapp. 2017. 38:5931-5942. Link to file >>

 

2016

Miyazaki Y, Song JW, Takahashi E. Asymmetry of radial and symmetry of tangential neuronal migration pathways in developing human fetal brains. Front. Neuroanat. 2016. 10:2. Link to file >>

Cohen AH, Wang R, Wilkinson M, MacDonald P, Lim AR, Takahashi E. Development of human white matter fiber pathways: From newborn to adult ages. Int J Dev Neurosci. 2016. 50:26-38. Link to file >>

Wilkinson M, Wang R, van der Kouwe A, Takahashi E. White and gray matter fiber pathways in autism spectrum Disorder Revealed by ex vivo Diffusion MR Tractography. Brain Behav. 2016. e00483. Link to file >>

Dai G, Das A, Hayashi E, Chen Q, Takahashi E. Regional variation of white matter development in the cat brain revealed by ex vivo diffusion MR tractography. Int J Dev Neurosci. 2016. 54:32-38. Link to file >>

Re TJ, Levman J, Lim AR, Righini A, Grant PE, Takahashi E. High-angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults. Brain Behav. 2016. 7(1):e00589. Link to file >>

Amamoto R, Huerta VGL, Takahashi E, Dai G, Grant AK, Fu Z, Arlotta P. Adult axolotls can regenerate original neuronal diversity in response to brain injury. eLife 2016. 5. pii: e13998. Link to file >>

Fame R, MacDonald J, Dunwoodie S, Takahashi E, Macklis J. Cited2 regulates neocortical layer II/III generation and somatosensory callosal projection neuron development and connectivity. J Neurosci. 2016. 36:6403- 6419. Link to file >>

 

2015

Wang R, Dai G, Takahashi E. High resolution MRI reveals detailed layer structures in early human fetal stages: In vitro study with histologic correlation. Front. Neuroanat. 2015. 9:150. Link to file >>

Song JW, Mitchell PD, Kolasinski J, Ellen Grant P, Galaburda AM, Takahashi E. Asymmetry of white matter pathways in developing human brains. Cereb Cortex. 2015. 25:2883-2893. Link to file >>

Baumer FM, Song JW, Michell PD, Pienaar R, Sahin M, Grant PE, Takahashi E. Longitudinal changes in diffusion properties in the white matter pathways of pediatric patients with tuberous sclerosis complex. Pediatric Neurology 2015. 52:615-623. Link to file >>

Re TJ, Scarciolla L, Takahashi E, Specchio N, Bernardi B, Longo D. Magnetic resonance fiber tracking in a neonate with hemimegalencephaly. J Neuroimaging. 2015. 25:844-847. Link to file >>

 

2014

Lodato S, Molyneaux BJ, Zuccaro E, Goff LA, Chen H-H, Yuan W, Meleski A, Takahashi E, Mahony S, Rinn JL, Gifford DK, Arlotta P. Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014. 17:1046-1054 Link to file >>

 

Other peer-reviewed scholarship

Tsujimura K, Shiohama T, Takahashi E. MicroRNA biology on brain development and neuroimaging approach. Brain Sci. 2022. 12:1366

Vasung L, Charvet CJ, Shiohama T, Gagoski B, Levman J, Takahashi E. Ex vivo fetal brain MRI: Recent advances, challenges, and future directions. Neuroimage 2019. 195:23-37. Link to file >>

Levman J, Takahashi E. Pre-adult MRI of brain cancer and neurological injury: multivariate analyses has. Front Pediatr. 2016. 23:4:65. Link to file >>

Levman J, Takahashi E. Multivariate analyses applied to healthy neurodevelopment in fetal, neonatal, and pediatric MRI. Front Neuroanat. 2015. 9:163. Link to file >>

Levman J, Takahashi E. Multivariate analyses applied to fetal, neonatal and pediatric MRI of neurodevelopmental disorders. Neuroimage:Clin. 2015. 9:532-44.-Clinical-review Link to file >>

 

Non-peer reviewed scientific or medical publications/materials in print or other media Proceedings of meetings or other non-peer reviewed research publications

Ortug A, Yuzbasioglu N, Akalan N, Takahashi E. Pre- and Post-operative HARDI Tractography of cerebellar pathways in posterior fossa tumors. American Association of Clinical Anatomists (AACA) 37th Annual Meeting. October 2020. doi: 10.1002/ca.23694

Charvet CJ, Das A, Song JW, Tindal-Burgess DJ, Kabaria P, Dai G, Kane T, Takahashi E. High angular resolution diffusion MRI reveals conserved and deviant programs in the paths that guide human cortical circuitry. bioRxiv 2019. doi: 10.1101/576967 Link to file >>

Charvet CJ, Palani A, Kabaria P, Takahashi E. Evolution of connections and cell types: integrating diffusion MR tractography with gene expression data highlights increased cortico-cortical projections in primates. bioRxive 2018. doi: 10.1101/493593

Levman J, Takahashi E. Identifying poor outcomes in autism as early as possible. Science. 2015. doi:10.1126/science.348.6233.409-f Comment.

 

Reviews, chapters, monographs and editorials

Levman J, Takahashi E. Editorial: Advanced Analytic Techniques in Developmental Neuroscience. Frontiers in Neuroscience, section Neurodevelopment. 2022.

Levman J, MacDonald P, Rowley S, Stewart N, Lim A, Ewenson B, Galaburda AM, Takahashi E. Structural magnetic resonance imaging demonstrates abnormal regionally-differential cortical thickness variability in pediatric autism. Front Hum Neurosci. 13:75. 2019. Frontiers in Human Neuroscience Research Topic e-Book. 2021. Link to file >>

Charvet CJ, Sherwood CC, Takahashi E. Developmental sequences predict increased connectivity in brain evolution: a comparative analysis of developmental timing, gene expression, neuron numbers, and diffusion MR tractography. In Evolution of Brain, Cognition and Emotion in Vertebrates (S. Watanabe, M. Hofman, T. Shimizu eds.). Elsevier. 2017. pp. 81-98. Link to file >>