Peer-reviewed publications and research investigations
2024
2023
Levman J, Kabaria P, Nangaku M, Takahashi E. Morphological abnormalities in early-onset schizophrenia revealed by structural magnetic resonance imaging. Biology 2023. 12:353.
2022
Levman J, Forgeron C, Shiohama T, MacDonald P, Stewart N, Lim A, Takahashi E. Cortical thickness abnormalities in attention deficit hyperactivity disorder revealed by structural magnetic resonance imaging: newborns to young adults. Int J Dev Neurosci. 2022. In press.
Levman J, Jennings M, Rouse E, Berger D, Kabaria P, Nangaku M, Gondra I and Takahashi E. A morphological study of schizophrenia with magnetic resonance imaging, advanced analytics, and machine learning. Front. Neurosci. 2022. 16:926426.
McCann B, Lam M, Shiohama T, Ijner P, Takahashi E, Levman J. Magnetic resonance imaging demonstrates gyral abnormalities in Tourette syndrome. Int J Dev Neurosci. 2022. In press.
Ortug A, Yuzbasioglu N, Akalan N, Levman J, Takahashi E. Preoperative and postoperative high angular resolution diffusion imaging tractography of cerebellar pathways in posterior fossa tumors. Clinical Anat. 2022. In press. doi.org/10.1002/ca.23914
Shiohama T, Ortug A, Alatorre Warren JL, Valli B, Levman J, Faja SK, Tsujimura K, Maunakea AK, Takahashi E. Small nucleus accumbens and large cerebral ventricles in infants and toddlers prior to receiving diagnoses of autism spectrum disorder. Cereb Cortex 2022. 32:1200-1211.
Shiohama T, Stewart N, Nangaku M, van der Kouwe AJW, Takahashi E. Identification of association fibers using ex vivo diffusion tractography in Alexander disease brains. J Neuroim. 2022. In press
2021
Guo Y‡, Ortug A‡, Sadberry R, Rezayev A, Levman J, Shiohama T, Takahashi E. Symptom-related differential neuroimaging biomarkers in children with corpus callosum abnormalities. Cereb Cortex 2021. 31: 4916- 4932. (‡ co-first authors)
Ijner P, Tompkins G, Shiohama T, Takahashi E, Levman J. Structural abnormalities in pediatric moyamoya disease revealed by clinical magnetic resonance imaging, regionally distributed relative signal intensities and volumes. Int J Dev Neurosci. 2021. Dec 30. https://doi.org/10.1002/jdn.10167
Levman J, Das A, MacDonald A, MacDonald P, Stewart N, Lim A, Berrigan L, Takahashi E. Clinically detectable structural abnormalities in pediatric onset multiple sclerosis: A large-scale magnetic resonance imaging analysis. Int J Dev Neurosci. 2021. 81:200-208.
Levman J, Jennings M, Kabaria P, Rouse E, Nangaku M, Berger D, Gondra I, Takahashi E, Tyrrell P. Hold-out validation for the assessment of stability and reliability of multivariable regression demonstrated with magnetic resonance imaging of patients with schizophrenia. Int J Dev Neurosci. 2021 Jul 26. doi:10.1002/jdn.10144. [Epub ahead of print]
McCann B, Levman J, Baumer N, Lam MY, Shiohama T, Cogger L, MacDonald A, Ijner P, Takahashi E. Structural magnetic resonance imaging demonstrates volumetric brain abnormalities in Down syndrome: Newborns to young adults. Neuroimage:Clin. 2021. Sep 3; 32:102815. doi: 10.1016/j.nicl.2021.102815 [Epub ahead of print]
Tompkins G, Levman J, Ijner P, Shiohama T, Takahashi E. Cortical thickness in clinical Moyamoya disease: a magnetic resonance imaging study. Int J Dev Neurosci. 2021. Aug 9. doi: 10.1002/jdn.10146 [Epub ahead of print]
2020
Charvet CJ, Das A, Song JW, Tindal-Burgess DJ, Kabaria P, Dai G, Kane T, Takahashi E. High angular resolution diffusion MRI reveals conserved and deviant programs in the paths that guide human cortical circuitry. Cereb Cortex 2020. 30:1447-1464.
Hendy JP, Takahashi E, Van der Kouwe A, Charvet CJ. Brain wiring and supragranuar-enriched genes linked to protracted human frontal cortex development. Cereb Cortex 2020. 30:5654-5666.
Shiohama T, Chew B, Levman J, Takahashi E. Quantitative analyses of high angular resolution diffusion imaging (HARDI)-derived long association fibers in children with sensorineural hearing loss. Int J Dev Neurosci. 2020. 80:717-729.
2019
Charvet CJ, Palani A, Kabaria P, Takahashi E. Evolution of brain connections: integrating diffusion MR tractography with gene expression highlights increased cortico-cortical projections in primates. Cereb Cortex 2019. 29:5150-5165.
Levman J, Fang Z, Zumwalt K, Cogger L, Vasung L, MacDonald P, Lim A, Takahashi E. Asymmetric insular connectomics revealed by diffusion magnetic resonance imaging analysis of healthy brain development. Brain Connect. 2019. 9:2-12.
Levman J, MacDonald P, Rowley S, Stewart N, Lim A, Ewenson B, Galaburda A, Takahashi E. Structural Magnetic Resonance Imaging Demonstrates Abnormal Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to Adults. Front Hum Neurosci. 2019 Mar 14;13:75. doi: 10.3389/fnhum.2019.00075.
Levman J, MacDonald A, Baumer N, MacDonald P, Stewart N, Lim A, Cogger L, Shiohama T, Takahashi E. Structural magnetic resonance imaging demonstrates abnormal cortical thickness in Down syndrome: Newborns to young adults. Neuroimage:Clin. 2019. 23:101874.
Shiohama T, Levman J, Takahashi E. Surface- and voxel-based brain morphologic study in Rett and Rett-like syndrome with MECP2 mutation. 2019. Int J Dev Neurosci. 73:83-88
Shiohama T, Levman J, Baumer N, Takahashi E. Structural MRI-based brain morphology study in infants and toddlers with Down syndrome; the effect of comorbidities. Pediatr Neurol. 2019. 100:67-73.
Shiohama T, McDavid J, Levman J, Takahashi E. Quantitative brain morphological analysis in CHARGE syndrome. Neuroimage:Clin. 2019. 23: 101866.
Shiohama T, McDavid J, Levman J, Takahashi E. The left lateral occipital cortex exhibits decreased thickness in children with sensorineural hearing loss. Int J Dev Neurosci. 2019. 76:34-40.
Vasung L, Rezayev A, Yun H, Song JW, Van der Kouwe A, Stewart N, Palani A, Shiohama T, Chouinard-Decorte F, Levman J, Takahashi E. Structural and diffusion MRI analyses with histological observations in patients with lissencephaly. Front Cell Dev Biol. 2019. 7:124.
2018
Das A, Takahashi E. Characterization of white matter tracts by diffusion MR tractography in cat and ferret that have similar gyral patterns. Cereb Cortex. 2018. 28:1338-1347.
Das A, Takahashi E. Neuronal migration and axonal pathways linked to human fetal insular development revealed by diffusion MR tractography. 2018. Cereb Cortex. 28:3555-3563.
Levman J, Takahashi E, Forgeron C, MacDonald P, Stewart N, Lim A, Martel A. A sorting statistic with application in neurological magnetic resonance imaging of autism. J. Healthcare Eng. 2018. 71:34-45.
Levman J, Vasung L, MacDonald P, Rowley S, Stewart N, Lim A, Ewenson B, Galaburda AM, Takahashi E. Regional volumetric abnormalities in pediatric autism revealed by structural magnetic resonance imaging. 2018. Int J Dev Neurosci. 71:34-45.
Kang D-W, Kim D, Chang L-H, KimY-H, Takahashi E, Cain MS, Watanabe T, Sasaki Y. Structural and functional connectivity changes beyond visual cortex in a later phase of visual perceptual learning. 2018. Sci Rep. 8:5186
Rezayev A, Feldman HA, Levman J, Takahashi E. Bilateral thalamocortical abnormalities in focal cortical dysplasia. Brain Res. 2018 Sep 1;1694:38-45. doi: 10.1016/j.brainres.2018.05.005. Epub 2018 May 5.
2017
Wilkinson M, Kane T, Wang R, Takahashi E. Migration pathways of thalamic neurons and development of thalamocortical connections in humans revealed by diffusion MR tractography. 2017. Cereb Cortex. 27:5683-5695.
Wilkinson M, Lim AR, Cohen AH, Galaburda AM, Takahashi E. Detection and growth pattern of arcuate fasciculus from newborn to adult. 2017. Front Neurosci. 11:389.
Charvet C, Hof P, Raghanti MA, van der Kouwe A, Sherwood C, Takahashi E. Combining diffusion MR tractography with stereology highlights increased cross-cortical integration in primates. J Comp Neurol. 2017. 525:1075-1093.
Charvet CJ, Šimić G, Kostović I, Kovačević V, Vukšić M, Leko MB, Takahashi E, Sherwood CC, Wolfe MD, Finlay BL. Co-evolution in the timing of GABAergic and pyramidal maturation in primates. Proc Royal Soc B: Biol Sci. 2017. 284:1861.
Kanamaru Y, Li J, Stewart N, Sidman RL, Takahashi E. Cerebellar pathways in mouse model of Purkinje cell degeneration detected by high-angular resolution diffusion imaging tractography. 2017. Cerebellum. 16:648-655.
Vasung L, Raguz M, Kostovic I, Takahashi E. Spatiotemporal relationship of brain pathways during human fetal development using high-angular resolution diffusion MR imaging and histology. 2017. Front Neurosci. 11:348.
Wang R, Wilkinson M, Kane T, Takahashi E. Convergence of cortical, thalamocortical, and callosal pathways during human fetal development revealed by diffusion MRI tractography. Front Neurosci. 2017. 11:576.
Levman J, MacDonald P, Lim AR, Takahashi E. A pediatric structural MRI analysis of healthy brain development from newborns to adults. Hum Brain Mapp. 2017. 38:5931-5942.
2016
Miyazaki Y, Song JW, Takahashi E. Asymmetry of radial and symmetry of tangential neuronal migration pathways in developing human fetal brains. Front. Neuroanat. 2016. 10:2.
Cohen AH, Wang R, Wilkinson M, MacDonald P, Lim AR, Takahashi E. Development of human white matter fiber pathways: From newborn to adult ages. Int J Dev Neurosci. 2016. 50:26-38.
Wilkinson M, Wang R, van der Kouwe A, Takahashi E. White and gray matter fiber pathways in autism spectrum Disorder Revealed by ex vivo Diffusion MR Tractography. Brain Behav. 2016. e00483.
Dai G, Das A, Hayashi E, Chen Q, Takahashi E. Regional variation of white matter development in the cat brain revealed by ex vivo diffusion MR tractography. Int J Dev Neurosci. 2016. 54:32-38.
Re TJ, Levman J, Lim AR, Righini A, Grant PE, Takahashi E. High-angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults. Brain Behav. 2016. 7(1):e00589.
Amamoto R, Huerta VGL, Takahashi E, Dai G, Grant AK, Fu Z, Arlotta P. Adult axolotls can regenerate original neuronal diversity in response to brain injury. eLife 2016. 5. pii: e13998.
Fame R, MacDonald J, Dunwoodie S, Takahashi E, Macklis J. Cited2 regulates neocortical layer II/III generation and somatosensory callosal projection neuron development and connectivity. J Neurosci. 2016. 36:6403- 6419.
2015
Wang R, Dai G, Takahashi E. High resolution MRI reveals detailed layer structures in early human fetal stages: In vitro study with histologic correlation. Front. Neuroanat. 2015. 9:150.
Song JW, Mitchell PD, Kolasinski J, Ellen Grant P, Galaburda AM, Takahashi E. Asymmetry of white matter pathways in developing human brains. Cereb Cortex. 2015. 25:2883-2893.
Baumer FM, Song JW, Michell PD, Pienaar R, Sahin M, Grant PE, Takahashi E. Longitudinal changes in diffusion properties in the white matter pathways of pediatric patients with tuberous sclerosis complex. Pediatric Neurology 2015. 52:615-623.
Re TJ, Scarciolla L, Takahashi E, Specchio N, Bernardi B, Longo D. Magnetic resonance fiber tracking in a neonate with hemimegalencephaly. J Neuroimaging. 2015. 25:844-847.
2014
Lodato S, Molyneaux BJ, Zuccaro E, Goff LA, Chen H-H, Yuan W, Meleski A, Takahashi E, Mahony S, Rinn JL, Gifford DK, Arlotta P. Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014. 17:1046-1054
Other peer-reviewed scholarship
Tsujimura K, Shiohama T, Takahashi E. MicroRNA biology on brain development and neuroimaging approach. Brain Sci. 2022. 12:1366
Vasung L, Charvet CJ, Shiohama T, Gagoski B, Levman J, Takahashi E. Ex vivo fetal brain MRI: Recent advances, challenges, and future directions. Neuroimage 2019. 195:23-37.
Levman J, Takahashi E. Pre-adult MRI of brain cancer and neurological injury: multivariate analyses has. Front Pediatr. 2016. 23:4:65.
Levman J, Takahashi E. Multivariate analyses applied to healthy neurodevelopment in fetal, neonatal, and pediatric MRI. Front Neuroanat. 2015. 9:163.
Levman J, Takahashi E. Multivariate analyses applied to fetal, neonatal and pediatric MRI of neurodevelopmental disorders. Neuroimage:Clin. 2015. 9:532-44.-Clinical-review
Non-peer reviewed scientific or medical publications/materials in print or other media Proceedings of meetings or other non-peer reviewed research publications
Ortug A, Yuzbasioglu N, Akalan N, Takahashi E. Pre- and Post-operative HARDI Tractography of cerebellar pathways in posterior fossa tumors. American Association of Clinical Anatomists (AACA) 37th Annual Meeting. October 2020. doi: 10.1002/ca.23694
Charvet CJ, Das A, Song JW, Tindal-Burgess DJ, Kabaria P, Dai G, Kane T, Takahashi E. High angular resolution diffusion MRI reveals conserved and deviant programs in the paths that guide human cortical circuitry. bioRxiv 2019. doi: 10.1101/576967
Charvet CJ, Palani A, Kabaria P, Takahashi E. Evolution of connections and cell types: integrating diffusion MR tractography with gene expression data highlights increased cortico-cortical projections in primates. bioRxive 2018. doi: 10.1101/493593
Levman J, Takahashi E. Identifying poor outcomes in autism as early as possible. Science. 2015. doi:10.1126/science.348.6233.409-f Comment.
Reviews, chapters, monographs and editorials
Levman J, Takahashi E. Editorial: Advanced Analytic Techniques in Developmental Neuroscience. Frontiers in Neuroscience, section Neurodevelopment. 2022.
Levman J, MacDonald P, Rowley S, Stewart N, Lim A, Ewenson B, Galaburda AM, Takahashi E. Structural magnetic resonance imaging demonstrates abnormal regionally-differential cortical thickness variability in pediatric autism. Front Hum Neurosci. 13:75. 2019. Frontiers in Human Neuroscience Research Topic e-Book. 2021.
Charvet CJ, Sherwood CC, Takahashi E. Developmental sequences predict increased connectivity in brain evolution: a comparative analysis of developmental timing, gene expression, neuron numbers, and diffusion MR tractography. In Evolution of Brain, Cognition and Emotion in Vertebrates (S. Watanabe, M. Hofman, T. Shimizu eds.). Elsevier. 2017. pp. 81-98.
